تفاعل #1605751

معادلة التفاعل

2-methylheptan-4-one

ammonium acetate

sodium cyanoborohydride

→

2-methylheptan-4-amine

المردود 77.2%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was removed under reduced pressure
2. 2
   workup.ADDITIONthe residue was diluted with water and basified with 15% NaOH aqueous
3. 3
   استخلاصextracted with ether
4. 4
   غسيلThe extract was washed with brine
5. 5
   تجفيفdried over anhydrous magnesium sulfate
6. 6
   ترشيحfiltered
7. 7
   أخرىevaporated

الإجراء التجريبي

To a solution of 2-methylheptan-4-one (4.24 g, 33.07 mmol), in methanol (60 mL), were added ammonium acetate (25.50 g, 330.71 mmol) and sodium cyanoborohydride (2.08 g, 33.07 mmol). The reaction mixture was stirred at room temperature for about 24 hours. The solvent was removed under reduced pressure and the residue was diluted with water and basified with 15% NaOH aqueous and extracted with ether. The extract was washed with brine, dried over anhydrous magnesium sulfate, filtered and evaporated to give 3.3 g of 2-methylheptan-4-amine (77%). MS (M+H, 130).

المصدر