تفاعل #160515

معادلة التفاعل

water

6-nitro-1H-indole

cesium carbonate

4-fluoro benzoic acid ethyl ester

→

title compound

المردود 66.9%

4-(6-Nitroindol-1-yl)benzoic acid ethyl ester

المردود 66.9%

المذيبات

N,N-dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   ترشيحthe precipitated solid was collected by filtration
2. 2
   غسيلwashed with water and n-hexane
3. 3
   أخرىdried under reduced pressure

الإجراء التجريبي

To a solution of 6-nitro-1H-indole (0.5 g) in N,N-dimethylformamide (10 mL) were added cesium carbonate (1.2 g) and 4-fluoro benzoic acid ethyl ester (0.62 g), and this mixture was stirred at 75° C. overnight. This reaction mixture was poured into water and the precipitated solid was collected by filtration, and washed with water and n-hexane, dried under reduced pressure to give the title compound (0.64 g).

المصدر