تفاعل #160420

معادلة التفاعل

2-bromo-N-(5-tert-butyl-isoxazol-3-yl)-2-methyl-propionamide

potassium thioacetate

→

thioacetic acid S-[1-(5-tert-butyl-isoxazol-3-ylcarbamoyl)-1-methyl-ethyl]ester

المردود 77.0%

المذيبات

diethyl ether

DMF

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with 2M aqueous HCl solution (5 mL)
2. 2
   تجفيفThe organic layer was dried over Na2SO4
3. 3
   ترشيحFiltration and concentration under reduced pressure

الإجراء التجريبي

To a solution of 200 mg (0.69 mmol) of 2-bromo-N-(5-tert-butyl-isoxazol-3-yl)-2-methyl-propionamide (prepared as described in Method B, step 2) in DMF (3 mL) were added 157 mg (1.4 mmol) of potassium thioacetate. The reaction was stirred at room temperature for 3 h. The reaction mixture was diluted with diethyl ether (5 mL) and washed with 2M aqueous HCl solution (5 mL). The organic layer was dried over Na2SO4. Filtration and concentration under reduced pressure afforded 151 mg of thioacetic acid S-[1-(5-tert-butyl-isoxazol-3-ylcarbamoyl)-1-methyl-ethyl]ester.

المصدر