تفاعل #1602448

معادلة التفاعل

ethyl 7-nitroindole-2-carboxylate

Lithium hydroxide hydrate

hydrochloric acid

→

title compound

7-Nitro-1H-indole-2-carboxylic acid

المذيبات

tetrahydrofuran

water

ظروف التفاعل

المعالجة

1. 1
   استخلاصthe reaction mixture was extracted with ethyl acetate
2. 2
   تجفيفThe extract was dried over anhydrous magnesium sulfate
3. 3
   ترشيحfiltered
4. 4
   workup.DISTILLATIONThe filtrate was distilled under reduced pressure

الإجراء التجريبي

Commercially available ethyl 7-nitroindole-2-carboxylate (500 mg, 2.14 mmol) was dissolved in a solvent mixture of tetrahydrofuran and water (1:1, 20 mL). Lithium hydroxide hydrate (448 mg, 10.7 mmol) was added thereto, and the mixture was stirred for 8 h at room temperature. 1N-hydrochloric acid solution was added, and the reaction mixture was extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate, and filtered. The filtrate was distilled under reduced pressure to give the title compound.

المصدر