تفاعل #1600904

معادلة التفاعل

Butyllithium

2-methylthiazole

Chlorotrimethylstannane

→

2-methyl-5-(trimethylstannyl)thiazole

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGStirring
2. 2
   workup.WAITwas continued at −78° C. for 45 min
3. 3
   أخرىThe reaction mixture was quenched with a satured aqueous solution of NaHCO3
4. 4
   استخلاصThe aqueous layer was extracted with Et2O
5. 5
   تجفيفThe organic extracts were dried over MgSO4
6. 6
   ترشيحfiltered
7. 7
   تركيزconcentrated in vacuo
8. 8
   أخرىUsed in the next step without purification (obtained 1.29 g)

الإجراء التجريبي

Butyllithium (1.6M in THF, 3.5 ml, 5.5 mmol) was added to a stirred solution of 2-methylthiazole (0.45 ml, 5.0 mmol) in THF (15 mL) at −78° C. The reaction mixture was stirred at −78° C. for 40 min. Chlorotrimethylstannane (1M in THF, 5.0 ml, 5.0 mmol) was added. Stirring was continued at −78° C. for 45 min. The reaction mixture was quenched with a satured aqueous solution of NaHCO3. The aqueous layer was extracted with Et2O. The organic extracts were dried over MgSO4, filtered and concentrated in vacuo. Used in the next step without purification (obtained 1.29 g). MS m/z=264.1. Calc'd for C ,7; H, 13; N, S, Sn: 261.94.

المصدر