تفاعل #159842

معادلة التفاعل

6-(bromomethyl)-3-methoxy-2-nitropyridine

methythioglycolate

potassium carbonate

→

Methyl 2-((5-methoxy-6-nitropyridin-2-yl)methylthio)acetate

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   تركيزAfter concentrated the mixture
2. 2
   أخرىwas purified by column chromatography

الإجراء التجريبي

A mixture of 6-(bromomethyl)-3-methoxy-2-nitropyridine (30 mmol, 0.74 g), methythioglycolate (2.7 mL, 30 mmol), and potassium carbonate (5.5 g, 40 mmol) in methanol (200 mL) was stirred at room temperature for 10 hours. After concentrated the mixture was purified by column chromatography using PE/DCM (1:1, v/v) followed by DCM to the titled compound. 1H-NMR (CDCl3): δ 3.27 (S, 2H, CH2), 3.74 (S, 3H, OCH3), 3.93 (S, 2H, CH2), 3.99 (S, 3H, OCH3), 7.51 (d, 1H, J=8.6 Hz, Py-H), 7.65 (d, 1H, J=8.6 Hz, Py-H); HR-MS (ESI+) m/z 272.0467 [M+H]+ C10H12N2O5S requires 273.0547.

المصدر