تفاعل #159742

معادلة التفاعل

bromo-cyclopropane

3,4-dihydro-2H-benzo[1,4]oxazine

potassium tert-butoxide

→

4-Cyclopropyl-3,4-dihydro-2H-benzo[1,4]oxazine

المردود 68.2%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGthe reaction mixture was stirred for another 4 h at room temperature
2. 2
   أخرىThe reaction was quenched by addition of water
3. 3
   استخلاصextracted with ethyl acetate (50×2 mL)
4. 4
   غسيلThe organic layer was washed with water (20 mL)
5. 5
   تركيزconcentrated
6. 6
   أخرىpurified by silica gel column chromatography

الإجراء التجريبي

To a stirred solution of 3,4-dihydro-2H-benzo[1,4]oxazine (5 g, 37.0 mmol) in DMF (20 mL) was added potassium tert-butoxide (6.22 g, 55.55 mmol) at 0° C. After stirring for 5 min, bromo-cyclopropane (4.44 mL, 55.55 mmol) was added and the reaction mixture was stirred for another 4 h at room temperature. The reaction was quenched by addition of water and extracted with ethyl acetate (50×2 mL). The organic layer was washed with water (20 mL), concentrated and purified by silica gel column chromatography to furnish 4-Cyclopropyl-3,4-dihydro-2H-benzo[1,4]oxazine (4.42 g).

المصدر