تفاعل #159731

معادلة التفاعل

4-(1-(5-chloro-2-(3-(3-fluorobenzoyl)azetidin-1-yl)nicotinamido)cyclopropyl)benzoic acid

O-methylhydroxylamine hydrochloride

→

title compound ( E26 )

المردود 22.9%

4-(1-(5-chloro-2-(3-((3-fluorophenyl)(methoxyimino)methyl)azetidin-1-yl)nicotinamido)cyclopropyl) benzoic acid

المردود 22.9%

المذيبات

pyridine

ظروف التفاعل

المعالجة

1. 1
   أخرىSolvents were evaporated in vacuo
2. 2
   workup.ADDITIONthe residue was diluted with water (5 ml)
3. 3
   استخلاصextracted with ethylacetate (3×20 ml)
4. 4
   أخرىCollected organics, after solvent evaporation
5. 5
   أخرىafforded a residue that
6. 6
   غسيلwas washed with methanol
7. 7
   أخرىdried in vacuo

الإجراء التجريبي

4-(1-(5-chloro-2-(3-(3-fluorobenzoyl)azetidin-1-yl)nicotinamido)cyclopropyl)benzoic acid (E25) (12.6 mg, 0.025 mmol) was dissolved in dry pyridine (1.2 ml) then O-methylhydroxylamine hydrochloride (4.3 mg, 0.051 mmol) was added and the resulting mixture was stirred at room temperature for 60 h. Solvents were evaporated in vacuo, and the residue was diluted with water (5 ml) and extracted with ethylacetate (3×20 ml). Collected organics, after solvent evaporation, afforded a residue that was washed with methanol and dried in vacuo to afford the title compound (E26) (D021/092/2) (3 mg).

المصدر