تفاعل #1596945

معادلة التفاعل

2-(4-benzyloxy-3-fluorophenyl)-4-bromo-5-propyltetrahydropyran

triethylamine

→

2-fluoro-4-(5-propyltetrahydropyran-2-yl)phenol

المذيبات

MTBE

toluene water

ظروف التفاعل

المعالجة

1. 1
   أخرىthe organic phase is separated off
2. 2
   استخلاصThe aqueous phase is extracted with MTBE
3. 3
   غسيلThe combined organic phases are washed with water
4. 4
   أخرىdried
5. 5
   تركيزThe solution is concentrated to dryness
6. 6
   أخرىthe residue is used directly for the following reaction

الإجراء التجريبي

123.0 g (0.30 mol) of 2-(4-benzyloxy-3-fluorophenyl)-4-bromo-5-propyltetrahydropyran are hydrogenated in toluene/water in the presence of Pd/C (5% of Pd) and 86.0 ml (0.60 mol) of triethylamine. The reaction solution is diluted with MTBE, and the organic phase is separated off. The aqueous phase is extracted with MTBE. The combined organic phases are washed with water and dried using sodium sulfate. The solution is concentrated to dryness, and the residue is used directly for the following reaction.

المصدر