تفاعل #1596940

معادلة التفاعل

phenyl isothiocyanate

2-amino-2-methyl-1-propanol

→

N-(1-hydroxy-2-methylpropan-2-yl)-N′-phenylthiourea

المردود 60.0%

المذيبات

chloroform

chloroform

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas slowly added dropwise to the mixture over one hour
2. 2
   workup.ADDITIONUpon completion of the addition
3. 3
   workup.STIRRINGthe resulting mixture was stirred for 12 hours at room temperature
4. 4
   درجة الحرارةThe precipitated crystals were refluxed
5. 5
   درجة الحرارةwith heat
6. 6
   workup.DISSOLUTIONto be dissolved
7. 7
   أخرىrecrystallized
8. 8
   أخرىThe crystals thus obtained
9. 9
   ترشيحwere collected by filtration
10. 10
    غسيلwashed with 20 mL of diethyl ether three times
11. 11
    أخرىdried under reduced pressure at room temperature

الإجراء التجريبي

In 500 g of chloroform was dissolved 2-amino-2-methyl-1-propanol (61.6 g, 0.69 moL). Then, 300 g of chloroform solution containing phenyl isothiocyanate (81.6 g, 0.6 moL) was slowly added dropwise to the mixture over one hour, while stirring. Upon completion of the addition, the resulting mixture was stirred for 12 hours at room temperature. The precipitated crystals were refluxed with heat to be dissolved and then recrystallized. The crystals thus obtained were collected by filtration, washed with 20 mL of diethyl ether three times, and then dried under reduced pressure at room temperature to give 80.1 g of N-(1-hydroxy-2-methylpropan-2-yl)-N′-phenylthiourea (yield 60%).

المصدر