تفاعل #159688

معادلة التفاعل

5-chloro-2-(3-(4-fluorophenyl)-3-hydroxyazetidin-1-yl)nicotinic acid

methyl 4-(1-aminocyclopropyl)benzoate hydrochloride

→

title compound ( D162 )

المردود 78.1%

methyl 4-(1-(5-chloro-2-(3-(4-fluorophenyl)-3-hydroxyazetidin-1-yl)nicotinamido)cyclopropyl)benzoate

المردود 78.1%

ظروف التفاعل

المعالجة

1. 1
   أخرىdescribed in Description 146 (reaction time 1 h)

الإجراء التجريبي

The title compound (D162) (76.7 mg) was prepared according to the experimental procedure described in Description 146 (reaction time 1 h) starting from 5-chloro-2-(3-(4-fluorophenyl)-3-hydroxyazetidin-1-yl)nicotinic acid (D112) (64 mg, 0.198 mmol) and methyl 4-(1-aminocyclopropyl)benzoate hydrochloride (D7) (45 mg, 0.198 mmol).

المصدر