تفاعل #1596523

معادلة التفاعل

diphenyliodonium chloride

triethylammonium 2-pivaloyloxy-1,1-difluoroethanesulfonate

water

→

target compound

المردود 96.6%

Diphenyliodonium 2-Pivaloyloxy-1,1-difluoroethanesulfonate

المردود 96.6%

المذيبات

chloroform

ظروف التفاعل

المعالجة

1. 1
   أخرىreacted at room temperature for 3 hours
2. 2
   أخرىThe thus-obtained reaction solution
3. 3
   أخرىwas separated into an organic layer
4. 4
   غسيلThe organic layer was washed five times with 15 mL of water
5. 5
   تركيزsubjected to concentration under reduced pressure

الإجراء التجريبي

In 10 mL of chloroform, 5 g of a solid of triethylammonium 2-pivaloyloxy-1,1-difluoroethanesulfonate (equivalent to 14.4 mmol) was dissolved by stirring. The resulting solution was admixed with 15 mL of water and 4.78 g (15.1 mmol) of diphenyliodonium chloride, and then, reacted at room temperature for 3 hours. The thus-obtained reaction solution was separated into an organic layer and an aqueous layer. The organic layer was washed five times with 15 mL of water and subjected to concentration under reduced pressure. With this, 7.32 g of the target compound was obtained as a white solid (purity: 90%, yield: 90%).

المصدر