تفاعل #159398

معادلة التفاعل

Potassium carbonate

5-cyclopentanecarbonyl-3-(2,2,2-trifluoroacetylamino)thiophene-2-carboxylic acid methyl ester

Water

ethyl acetate

→

3-Amino-5-cyclopentanecarbonylthiophene-2-carboxylic acid methyl ester

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe organic phase was separated off
2. 2
   استخلاصthe aqueous phase was re-extracted twice with ethyl acetate
3. 3
   تجفيفThe combined organic phases were dried over magnesium sulfate
4. 4
   تركيزconcentrated
5. 5
   أخرىThe product with the molecular weight of 253.32 (C12H15NO3S) was obtained in this way

الإجراء التجريبي

Potassium carbonate (2.275 g) was added to a solution of 5-cyclopentanecarbonyl-3-(2,2,2-trifluoroacetylamino)thiophene-2-carboxylic acid methyl ester (1.150 g) in methanol (17 mL), and the mixture was stirred at room temperature for 2 h. Water and ethyl acetate were added. The organic phase was separated off, and the aqueous phase was re-extracted twice with ethyl acetate. The combined organic phases were dried over magnesium sulfate and concentrated. The product with the molecular weight of 253.32 (C12H15NO3S) was obtained in this way; MS (ESI): 254 (M+H+).

المصدر