تفاعل #159393

معادلة التفاعل

5-cyclopropylethynyl-3-nitrothiophene-2-carboxylic acid methyl ester

→

3-Amino-5-(2-cyclopropylethyl)thiophene-2-carboxylic acid methyl ester

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe catalyst was then filtered off through kieselguhr
2. 2
   أخرىthe solvent was removed in vacuo
3. 3
   أخرىThe product with the molecular weight of 225.31 (C11H15NO2S) was obtained in this way

الإجراء التجريبي

A suspension of 5-cyclopropylethynyl-3-nitrothiophene-2-carboxylic acid methyl ester (1.0 g) and palladium (5% on carbon) (170 mg) in methanol (50 mL) was vigorously stirred under an atmosphere of hydrogen at atmospheric pressure for 5 h. The catalyst was then filtered off through kieselguhr, and the solvent was removed in vacuo. The product with the molecular weight of 225.31 (C11H15NO2S) was obtained in this way; MS (ESI): 226 (M+H+).

المصدر