تفاعل #159376

معادلة التفاعل

4-fluoro-2-methyl-1-nitrobenzene

dimethylpyrrolidin-3-ylamine

potassium carbonate

→

Dimethyl-[1-(3-methyl-4-nitrophenyl)pyrrolidin-3-yl]amine

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction mixture was partitioned between water and ethyl acetate
2. 2
   أخرىThe organic phase was dried
3. 3
   تركيزconcentrated
4. 4
   أخرىThe product with the molecular weight of 249.32 (C13H19N3O2) was obtained in this way

الإجراء التجريبي

A mixture of 4-fluoro-2-methyl-1-nitrobenzene (13.6 g), dimethylpyrrolidin-3-ylamine (10.0 g), potassium carbonate (12 g) and DMF (100 mL) was stirred at room temperature for 4 hours. The reaction mixture was partitioned between water and ethyl acetate. The organic phase was dried and concentrated. The product with the molecular weight of 249.32 (C13H19N3O2) was obtained in this way; MS (ESI): 250 (M+H+).

المصدر