تفاعل #159374

معادلة التفاعل

3-amino-5-(4-chlorophenyl)thiophene-2-carboxylic acid methyl ester

dimethoxymethyldimethylamine

→

5-(4-Chlorophenyl)-3-(dimethylaminomethyleneamino)thiophene-2-carboxylic acid methyl ester

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction solution was partitioned between water and ethyl acetate
2. 2
   تجفيفThe organic phase was dried over magnesium sulfate
3. 3
   تركيزconcentrated
4. 4
   أخرىThe product with the molecular weight of 322.82 (C15H15ClN2O2S) was obtained in this way

الإجراء التجريبي

A solution of 3-amino-5-(4-chlorophenyl)thiophene-2-carboxylic acid methyl ester (5.0 g) in DMF (30 μL) was mixed with dimethoxymethyldimethylamine (5 mL) and stirred for 36 hours. The reaction solution was partitioned between water and ethyl acetate. The organic phase was dried over magnesium sulfate and concentrated. The product with the molecular weight of 322.82 (C15H15ClN2O2S) was obtained in this way; MS (ESI): 323 (M+H+).

المصدر