تفاعل #159328

معادلة التفاعل

(3R)—N-(8-azabicyclo[3.2.1]octan-3-yl)-3-(5-cyanopyridin-2-ylamino)pyrrolidine-1-carboxamide

i-Pr2NEt

methanesulfonyl chloride

→

title compound

المردود 58.6%

(3R)-3-(5-cyanopyridin-2-ylamino)-N-(8-(methylsulfonyl)-8-azabicyclo[3.2.1]octan-3-yl)pyrrolidine-1-carboxamide

المردود 58.6%

المذيبات

HOAc

MeOH

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   أخرىpurified by prep HPLC

الإجراء التجريبي

To a stirred solution of (3R)—N-(8-azabicyclo[3.2.1]octan-3-yl)-3-(5-cyanopyridin-2-ylamino)pyrrolidine-1-carboxamide (18 mg, 0.053 mmol) and i-Pr2NEt (0.075 mL, 0.4 mmol) in CH2Cl2 (1 mL) was added methanesulfonyl chloride (0.008 mL, 0.10 mmol). The mixture was stirred overnight at rt, diluted with HOAc (0.1 mL) and MeOH (0.9 mL) and purified by prep HPLC to afford the title compound (13 mg, 58%). LC-MS Method 1 tR=1.1 min, m/z=419; 1H NMR (CD3OD) [selected resonances] 2.93 (s, 3H), 4.47 (m, 1H), 6.78 (d, 1H), 7.77 (d, 1H), 8.40 (s, 1H)

المصدر