تفاعل #159321

معادلة التفاعل

methyl 9-oxobicyclo[3.3.1]nonane-3-carboxylate

NaBH4

→

methyl 9-hydroxybicyclo-[3.3.1]nonane-3-carboxylate

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   تركيزconcentrated
2. 2
   workup.ADDITIONThe residue was diluted with water
3. 3
   استخلاصthe mixture was extracted with Et2O
4. 4
   تركيزThe organic layer was concentrated

الإجراء التجريبي

To a solution of methyl 9-oxobicyclo[3.3.1]nonane-3-carboxylate (190 mg, 0.97 mmol) in methanol was added NaBH4 (76 mg, 2 mmol) at 0° C. The mixture was stirred at rt for 2 h, and concentrated. The residue was diluted with water, and the mixture was extracted with Et2O. The organic layer was concentrated to give methyl 9-hydroxybicyclo-[3.3.1]nonane-3-carboxylate, which was used in the next step directly without purification (140 mg, crude).

المصدر