تفاعل #159056

معادلة التفاعل

2,7-dibromo-9,9-difluoro-9H-fluorene

tributyl(1-ethoxyvinyl)tin

DIEA

NBS

Boc-L-Pro-OH

→

pyrrolidine-1,2-dicarboxylic acid 2-[2-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-oxo-ethyl]ester 1-tert-butyl ester

المردود 34.0%

المذيبات

dioxane

EtOAc

ethyl acetate

MeCN

DMF

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe reaction was cooled to room temperature
2. 2
   غسيلwashed with saturated sodium bicarbonate solution
3. 3
   تجفيفThe organic layer dried (MgSO4)
4. 4
   تركيزconcentrated down
5. 5
   workup.DISSOLUTIONThe residue was dissolved in 15 mL anhydrous DMF
6. 6
   workup.STIRRINGThe reaction was stirred at room temperature for 3 hours
7. 7
   أخرىThe reaction crude
8. 8
   غسيلwashed with saturated sodium bicarbonate solution
9. 9
   تجفيفThe organic layer dried (MgSO4)
10. 10
    تركيزconcentrated
11. 11
    أخرىpurified by flash column chromatography (silica gel, 20 to 100% ethyl acetate/hexane)

الإجراء التجريبي

[1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium(II) (5%, 82 mg) and tetrakis(triphenylphosphine)palladium (5%, 115 mg) were added to the mixture of 2,7-dibromo-9,9-difluoro-9H-fluorene (720 mg, 3 mmol) and tributyl(1-ethoxyvinyl)tin (1 eq., 0.677 mL) in 12 mL dioxane. The reaction was heated to 70° C. under Argon for 4 hours. The reaction was cooled to room temperature. 3 mL water was added and followed by NBS (1 eq., 356 mg). The reaction was stirred at room temperature overnight. The reaction mixture was dissolved in ethyl acetate and washed with saturated sodium bicarbonate solution. The organic layer dried (MgSO4), concentrated down. The residue was dissolved in 15 mL anhydrous DMF. Boc-L-Pro-OH (4 eq., 1.72 g) was added, followed by DIEA (3.5 eq., 1.22 mL) in 5 mL MeCN and 5 mL DMF dropwise. The reaction was stirred at room temperature for 3 hours. The reaction crude was diluted with EtOAc and washed with saturated sodium bicarbonate solution. The organic layer dried (MgSO4), concentrated and purified by flash column chromatography (silica gel, 20 to 100% ethyl acetate/hexane) to give pyrrolidine-1,2-dicarboxylic acid 2-[2-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-oxo-ethyl]ester 1-tert-butyl ester (363 mg, yield 34%). LCMS-ESI−: calc'd for C25H24BrF2NO5: 536.36. Found: 560.0 (M+Na+), 535.9 (M−H).

المصدر