تفاعل #159028

معادلة التفاعل

{1-[2-(5-Ethynyl-1H-imidazol-2-yl)-pyrrolidine-1-carbonyl]-2-methyl-propyl}-carbamic acid methyl ester

1,4-dibromobenzene

triethylamine

→

(1-{2-[5-(4-Bromo-phenylethynyl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

المردود 51.0%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىthe mixture was degassed for 10 min with nitrogen
2. 2
   workup.ADDITIONthen diluted with 20 mL ethyl acetate
3. 3
   غسيلwashed with saturated aqueous sodium bicarbonate and brine
4. 4
   تجفيفThe organic phase was dried with magnesium sulfate
5. 5
   تركيزconcentrated
6. 6
   أخرىThe crude residue was purified by silica column chromatography (0% to 5% MeOH/DCM)

الإجراء التجريبي

{1-[2-(5-Ethynyl-1H-imidazol-2-yl)-pyrrolidine-1-carbonyl]-2-methyl-propyl}-carbamic acid methyl ester (57 mg, 0.179 mmol), 1,4-dibromobenzene (211 mg, 0.895 mmol), Pd(PPh3)4 (10 mg, 0.00895 mmol), CuI (3 mg, 0.0179 mmol) and triethylamine (0.249 mL, 1.79 mmol) were suspended in DMF (2 mL) and the mixture was degassed for 10 min with nitrogen. The reaction mixture was stirred at 80° C. for 70 min then diluted with 20 mL ethyl acetate and washed with saturated aqueous sodium bicarbonate and brine. The organic phase was dried with magnesium sulfate and concentrated. The crude residue was purified by silica column chromatography (0% to 5% MeOH/DCM) to afford (1-{2-[5-(4-Bromo-phenylethynyl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester (43 mg, 51%).

المصدر