تفاعل #159000

معادلة التفاعل

4,4′-Ethylenedianiline

pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

1-ethoxycarbonyl-1,2-dihydroquinoline

→

pyrrolidine-1-carboxylic acid tert-butyl ester

المردود 147.2%

المذيبات

DCM

ظروف التفاعل

المعالجة

1. 1
   أخرىevaporated under vacuum
2. 2
   workup.DISSOLUTIONOil was dissolved in ethyl acetate
3. 3
   أخرىforming a precipitate, which
4. 4
   ترشيحwas collected by vacuum filtration
5. 5
   أخرىdried under vacuum

الإجراء التجريبي

4,4′-Ethylenedianiline (2.98 g) and pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester (7.09 g) were dissolved in DCM (90 mL), and 1-ethoxycarbonyl-1,2-dihydroquinoline (8.38 g) was added. The reaction mixture was stirred at ambient temperature for 3 hours and evaporated under vacuum. Oil was dissolved in ethyl acetate, forming a precipitate, which was collected by vacuum filtration and dried under vacuum, giving 2-[4-(2-{4-[(1-carboxylic acid tert-butyl ester-pyrrolidine-2-carbonyl)-amino]-phenyl}-ethyl)-phenylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (8.30 g, 97%) as a white solid.

المصدر