تفاعل #1588355

معادلة التفاعل

methyl 4-(1-hydroxyethyl)benzoate

cyclohexanol

bismuth (III) bromide

→

methyl 4-(1-(cyclohexyloxy)ethyl)benzoate

المردود 14.0%

المذيبات

carbon tetrachloride

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGthe mixture was stirred at room temperature for 12 hours
2. 2
   تركيزThen the mixture was concentrated
3. 3
   أخرىpurified by column chromatography (silica gel, Petroleum ether/ethyl acetate=20:1)

الإجراء التجريبي

To the solution of cyclohexanol (167 mg, 1.67 mmol) in carbon tetrachloride (50 mL) was added bismuth (III) bromide (744.4 mg, 1.67 mmol), the mixture was stirred for 30 minutes at room temperature, the methyl 4-(1-hydroxyethyl)benzoate (300 mg, 1.67 mmol) was added, the mixture was stirred at room temperature for 12 hours. Then the mixture was concentrated and purified by column chromatography (silica gel, Petroleum ether/ethyl acetate=20:1) to give methyl 4-(1-(cyclohexyloxy)ethyl)benzoate (60 mg, 14%) as oil.

المصدر