تفاعل #158392

معادلة التفاعل

5-(4-bromo-2-methoxyphenyl)-2-methyl-1,3-oxazole

5-chloropent-1-yne

triethylamine

→

title compound

5-[4-(5-chloropent-1-yn-1-yl)-2-methoxyphenyl]-2-methyl-1,3-oxazole

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   ترشيحthe mixture was filtered through celite
2. 2
   أخرىThe solvent was evaporated under reduced pressure
3. 3
   أخرىthe residue was purified by silica gel column chromatography (ethyl acetate/hexane)

الإجراء التجريبي

A mixture of 5-(4-bromo-2-methoxyphenyl)-2-methyl-1,3-oxazole (6.00 g), 5-chloropent-1-yne (4.74 mL), dichlorobis(triphenylphosphine)palladium(II) (1.57 g), copper(I) iodide (426 mg) and triethylamine (60 mL) was stirred at 70° C. for 3 hr, and diluted with ethyl acetate, and the mixture was filtered through celite. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (4.85 g).

المصدر