تفاعل #1583879

معادلة التفاعل

2,2-diphenyl ethanol

triethylamine

MsCl

→

2,2-diphenylethyl methanesulfonate

المردود 96.8%

المذيبات

dichloromethane

—

three-opening

ظروف التفاعل

المعالجة

1. 1
   أخرىwas conducted at 25° C
2. 2
   أخرىAfter the completion of reaction
3. 3
   غسيلthe reaction solution was washed with water thrice
4. 4
   تجفيفThe organic phase was dried over anhydrous sodium sulfate
5. 5
   أخرىevaporated
6. 6
   أخرىto remove the solvent

الإجراء التجريبي

In a 500 mL three-opening flask, 2,2-diphenyl ethanol (17 g, 86 mmol) was dissolved in 170 mL dichloromethane. To the flask was added triethylamine (13.03 g, 129 mmol). The resulting mixture was stirred at 0° C. for half an hour. To the resulting mixture was slowly added MsCl (11.92 g, 104 mmol) dropwisely. The reaction was conducted at 25° C. After the completion of reaction monitored by TLC, the reaction solution was washed with water thrice. The organic phase was dried over anhydrous sodium sulfate and evaporated to remove the solvent to produce 2,2-diphenylethyl methanesulfonate (23 g) in a yield of 96.78%.

المصدر