تفاعل #1583867

معادلة التفاعل

dimethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

NaOH

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title product

المردود 57.2%

5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid

المردود 57.2%

المذيبات

methanol

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىwas conducted at 70° C.
2. 2
   workup.STIRRINGunder violent stirring for 6 hours
3. 3
   أخرىevaporated under reduced pressure
4. 4
   أخرىto remove 80 mL methanol
5. 5
   workup.ADDITIONTo the residue was added 200 mL water
6. 6
   أخرىThe unreacted starting materials are removed by filtration
7. 7
   أخرىto separate a yellow solid, which
8. 8
   ترشيحwas filtered
9. 9
   أخرىdried
10. 10
    أخرىto produce a khaki powder

الإجراء التجريبي

3.5 g dimethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (0.01 mol) and 150 mL methanol were mixed. To the mixture was added a saturated aqueous NaOH solution (9 g, 0.225 mol) under stirring. The reaction was conducted at 70° C. under violent stirring for 6 hours, and evaporated under reduced pressure to remove 80 mL methanol. To the residue was added 200 mL water. The unreacted starting materials are removed by filtration. The filtrate was adjusted to a pH of about 2.5 with 1 mol/L hydrochloric acid to separate a yellow solid, which was filtered and dried to produce a khaki powder. The resulting powder was treated with methanol to produce the title product as a yellow solid (1.9 g) in a yield of 57.2%.

المصدر