تفاعل #1583858

معادلة التفاعل

venlafaxine HCl

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Venlafaxine

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONslowly adding 1,000 g of AMBERLITE™
2. 2
   workup.ADDITIONThe dispersion was mixed for 4 hours and upon completion
3. 3
   أخرىbefore decanting the supernatant
4. 4
   أخرىThe wet resin complex was then dried in a VWR™ convection oven
5. 5
   workup.ADDITIONEUDRAGIT™ NE-30D polymer of 467 g was then slowly added to the wet resin complex in a Hobart type mixer (Kitchen Aid)
6. 6
   أخرىto form a uniform mass
7. 7
   أخرىThe wet mass was dried in a 50° C
8. 8
   أخرىThe dried granules were then milled through a 40 mesh screen

الإجراء التجريبي

The Venlafaxine Resin Complex was prepared by first dissolving 500 g of venlafaxine HCl in 5 L of purified water, and then slowly adding 1,000 g of AMBERLITE™ IRP-69 resin with continuous mixing. The dispersion was mixed for 4 hours and upon completion, allowed to settle before decanting the supernatant. The slurring/decanting process was repeated twice with sufficient amounts of purified water. The wet resin complex was then dried in a VWR™ convection oven maintained at 50° C. until moisture content was about 25%. EUDRAGIT™ NE-30D polymer of 467 g was then slowly added to the wet resin complex in a Hobart type mixer (Kitchen Aid) to form a uniform mass. The wet mass was dried in a 50° C. VWR™ convection oven to the moisture content around 4-6%. The dried granules were then milled through a 40 mesh screen using CO-MIL™ brand mill.

المصدر