تفاعل #1583806

معادلة التفاعل

methyl 2,4-dichloro-3-hydroxybenzoate

potassium carbonate

nonafluoro-n-butanesulfonyl chloride

→

clean product

المردود 16.2%

methyl 2,4-dichloro-3-(nonafluoro-n-butylsulfonyloxy)benzoate

المردود 16.2%

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONFor workup, the contents were poured onto ice-water
2. 2
   استخلاصthe mixture was extracted with ethyl acetate
3. 3
   أخرىThe organic phase was dried
4. 4
   أخرىthe filtrate was freed of the solvent on a rotary evaporator
5. 5
   أخرىThe residue was purified by chromatography, which

الإجراء التجريبي

9.5 g (43.0 mmol) of methyl 2,4-dichloro-3-hydroxybenzoate in 240 ml of acetonitrile were admixed with 8.6 g (62.2 mmol) of potassium carbonate and then with 9.5 ml (52.8 mmol) of nonafluoro-n-butanesulfonyl chloride. The reaction mixture was stirred at room temperature (RT) for 16 h. For workup, the contents were poured onto ice-water and the mixture was extracted with ethyl acetate. The organic phase was dried and the filtrate was freed of the solvent on a rotary evaporator. The residue was purified by chromatography, which gave 3.5 g of clean product.

المصدر