تفاعل #1581926

معادلة التفاعل

1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4- oxoquinoline-3-carboxylic acid

4-fluoroisoindoline

→

target compound

المردود 66.1%

7(4-fluoro-2-isoindolinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

المردود 66.1%

المذيبات

DMF

ظروف التفاعل

الإجراء التجريبي

136 mg of 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4- oxoquinoline-3-carboxylic acid, 206 mg of 4-fluoroisoindoline, and 1.5 ml of anhydrous DMF were processed in the same manner as in Example 20 to produce 127 mg of the target compound.

المصدر