تفاعل #1581925

معادلة التفاعل

9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]-benzoxazine-6-carboxylic acid

4-fluoroisoindoline

→

target compound

المردود 35.5%

10-(4-fluoro-2-isoindolinyl)-9-fluoro-2,3-dihydro-3-methyl- 7-oxo-7H-pyrido[1,2,3-de][1,4]-benzoxazine-6-carboxylic acid

المردود 35.5%

المذيبات

DMF

ظروف التفاعل

الإجراء التجريبي

141 mg of 9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]-benzoxazine-6-carboxylic acid, 206 mg of 4-fluoroisoindoline, and 1.5 ml of anhydrous DMF were processed in the same manner as in Example 20 to produce 71 mg of the target compound.

المصدر