تفاعل #157763

معادلة التفاعل

water

Potassium carbonate

(3-bromopropoxy)-tert-butyldimethylsilane

4-bromothiophenol

→

title compound

المردود 95.9%

{3-[(4-Bromophenyl)sulfanyl]propoxy}(tert-butyl)dimethylsilane

المردود 95.9%

المذيبات

N,N-dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   استخلاصfollowed by extraction with ethyl acetate
2. 2
   غسيلThe organic layer was washed with brine
3. 3
   تجفيفdried over anhydrous magnesium sulfate
4. 4
   ترشيحfiltered
5. 5
   أخرىThe solvent was then evaporated under reduced pressure
6. 6
   أخرىThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=50:1→20:1)

الإجراء التجريبي

Potassium carbonate (4.1 g) and (3-bromopropoxy)-tert-butyldimethylsilane (4.1 g) were added to a solution of 4-bromothiophenol (3.0 g) in N,N-dimethylformamide, and the mixture was stirred at room temperature overnight. The reaction solution was poured into water, followed by extraction with ethyl acetate. The organic layer was washed with brine, dried over anhydrous magnesium sulfate and filtered. The solvent was then evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=50:1→20:1) to give the title compound as a colorless oil (5.5 g).

المصدر