تفاعل #157534

معادلة التفاعل

2-amino-4-chlorobenzenethiol

N,N-dimethylacrylamide

HOAc

→

title compound

المردود 54.0%

3-[(2-amino-4-chlorophenyl)thio]-N,N-dimethylpropanamide

المردود 54.0%

المذيبات

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction was quenched with NaHCO3 (aq.)
2. 2
   استخلاصextracted with CH2Cl2 (2×10 ml)
3. 3
   غسيلThe organic layer was washed with water and brine
4. 4
   تركيزconcentrated in vacuo
5. 5
   أخرىThe crude product was purified by chromatography on silica gel (50% ethyl acetate in hexane)

الإجراء التجريبي

A mixture of 2-amino-4-chlorobenzenethiol (327 mg, 2.05 mmol), N,N-dimethylacrylamide (203 mg, 2.05 mmol) and HOAc (0.5 ml) in CH2Cl2 (5 ml) was stirred at room temperature for 3 days. The reaction was quenched with NaHCO3 (aq.) and then extracted with CH2Cl2 (2×10 ml). The organic layer was washed with water and brine and concentrated in vacuo. The crude product was purified by chromatography on silica gel (50% ethyl acetate in hexane) to yield the title compound (284 mg, 54%).

المصدر