تفاعل #157309

معادلة التفاعل

3-Hydroxy-2-aminopyridine

potassium hydroxide

carbon disulfide

→

title compound

المردود 91.0%

Oxazolo[4,5-b]pyridine-2(3H)-thione

المردود 91.0%

المذيبات

EtOH

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto reflux overnight
2. 2
   تركيزthe reaction mixture was concentrated under reduced pressure
3. 3
   ترشيحcollected by filtration
4. 4
   غسيلwashed with water (2×)
5. 5
   أخرىair-dried
6. 6
   أخرىFurther drying in a 35° C. vacuum oven

الإجراء التجريبي

3-Hydroxy-2-aminopyridine (2.00 g, 18.2 mmol) and potassium hydroxide (1.22 g, 21.8 mmol) were dissolved in carbon disulfide (15 mL) and EtOH (25 mL), and the reaction mixture was heated to reflux overnight. Upon cooling to rt, the reaction mixture was concentrated under reduced pressure. The resulting solid was suspended in 1 M aqueous HCl, collected by filtration, washed with water (2×) and air-dried. Further drying in a 35° C. vacuum oven gave 2.52 g (91%) of the title compound as a tan solid. LC-MS: RT=4.82 min., [M+H]+=153.1

المصدر