تفاعل #157154

معادلة التفاعل

4,6-dichloropyridin-2-amine

K2CO3

Et2Zn

→

4-chloro-6-ethylpyridin-2-amine

المردود 33.0%

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةUpon cooling to room temperature
2. 2
   استخلاصthe mixture was extracted with EtOAc
3. 3
   تجفيفdried with Na2SO4
4. 4
   تركيزconcentrated
5. 5
   أخرىThe crude material was purified via SiO2 column chromatography
6. 6
   غسيلeluting with DCM/MeOH (2%)

الإجراء التجريبي

To a solution of 4,6-dichloropyridin-2-amine (1.0 equiv.) in THF (0.1M) was added Pd(dppf)Cl2-DCM (0.1M), K2CO3 (3.0 equiv.), and Et2Zn (1.2 equiv.). The reaction was heated to 70° C. for 18 hrs. Upon cooling to room temperature, NH4Cl(sat.) was added, the mixture was extracted with EtOAc, dried with Na2SO4, and concentrated. The crude material was purified via SiO2 column chromatography eluting with DCM/MeOH (2%) to yield 4-chloro-6-ethylpyridin-2-amine in 33% yield. LCMS (m/z): 157.1 (MH+).

المصدر