تفاعل #157018

معادلة التفاعل

4-chloro-3-nitropyridine

tert-butyl pyrrolidin-3-ylcarbamate

DIEA

→

tert-butyl 1-(3-nitropyridin-4-yl)pyrrolidin-3-ylcarbamate

المردود 95.0%

المذيبات

EtOH

ظروف التفاعل

الإجراء التجريبي

The method of Example 1 was followed using 4-chloro-3-nitropyridine (1.0 eq), tert-butyl pyrrolidin-3-ylcarbamate (2.0 eq), and DIEA (2.0 eq) in EtOH yielding tert-butyl 1-(3-nitropyridin-4-yl)pyrrolidin-3-ylcarbamate (95%) LCMS (m/z): 309.1 (MH+); LC Rt=1.922 min.

المصدر