تفاعل #1566908

معادلة التفاعل

methyl 4-(1-hydroxyethyl)benzoate

methanol

bismuth (III) bromide

→

methyl-4-(1-methoxyethyl)benzoate

المردود 57.0%

المذيبات

perchloromethane

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGthe mixture was stirred at room temperature for 12 hours
2. 2
   تركيزThen the mixture was concentrated
3. 3
   أخرىpurified by column chromatography (silica gel, Petroleum ether/ethyl acetate=20:1)

الإجراء التجريبي

To the solution of methanol (53 mg, 1.67 mmol) in perchloromethane (80 mL) was added bismuth (III) bromide (743 mg, 1.67 mmol), the mixture was stirred for 30 minutes at room temperature, the methyl 4-(1-hydroxyethyl)benzoate (300 mg, 1.67 mmol) was added, the mixture was stirred at room temperature for 12 hours. Then the mixture was concentrated and purified by column chromatography (silica gel, Petroleum ether/ethyl acetate=20:1) to give methyl-4-(1-methoxyethyl)benzoate (185 mg, 57%), as oil.

المصدر