تفاعل #156644

معادلة التفاعل

2-[4-(1,4-dioxa-7-aza-spiro[4.4]non-7-yl)-3-fluorophenyl]-6-hydroxy-3,4-dihydro-2H-isoquinolin-1-one

(S)-2-methanesulfonylmethyl-tetrahydrofuran

cesium carbonate

→

2-[4-(1,4-Dioxa-7-aza-spiro[4.4]non-7-yl)-3-fluorophenyl]-6-[(S)-1-(tetrahydrofuran-2-yl)methoxy]-3,4-dihydro-2H-isoquinolin-1-one

المذيبات

ethyl acetate

water

DMF

ظروف التفاعل

المعالجة

1. 1
   غسيلThe organic phase was washed several times with water
2. 2
   تجفيفdried over sodium sulfate
3. 3
   أخرىthe solvent was removed in vacuum
4. 4
   أخرىIn this way the product was obtained with molecular weight 468.53 (C26H29FN2O5)

الإجراء التجريبي

A mixture of 2-[4-(1,4-dioxa-7-aza-spiro[4.4]non-7-yl)-3-fluorophenyl]-6-hydroxy-3,4-dihydro-2H-isoquinolin-1-one (6.9 g), (S)-2-methanesulfonylmethyl-tetrahydrofuran (3.9 g) and cesium carbonate (17.6 g) in DMF (81.6 mL) was heated overnight at 75° C. Then the reaction mixture was diluted with ethyl acetate and water. The organic phase was washed several times with water, dried over sodium sulfate and the solvent was removed in vacuum. In this way the product was obtained with molecular weight 468.53 (C26H29FN2O5); MS (ESI): 469 (M+H+).

المصدر