تفاعل #156596

معادلة التفاعل

Trifluoromethanesulfonic anhydride

2-[4-((R)-3-dimethylaminopyrrolidin-1-yl)-3-fluorophenyl]-6-hydroxy-3,4-dihydro-2H-isoquinolin-1-one

pyridine

→

Trifluoromethanesulfonic acid 2-[4-((R)-3-dimethylaminopyrrolidin-1-yl)-3-fluorophenyl]-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl ester

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىthe mixture was partitioned between water and dichloromethane
2. 2
   تجفيفthe organic phase was dried over magnesium sulfate
3. 3
   تركيزconcentrated
4. 4
   أخرىThe product with the molecular weight of 501.50 (C22H23F4N3O4S) was obtained in this way

الإجراء التجريبي

Trifluoromethanesulfonic anhydride (2.06 g) was added to a solution of 2-[4-((R)-3-dimethylaminopyrrolidin-1-yl)-3-fluorophenyl]-6-hydroxy-3,4-dihydro-2H-isoquinolin-1-one (1.5 g) and pyridine (0.64 g) in dichloromethane (40 mL) at 0° C. After 30 minutes, the mixture was partitioned between water and dichloromethane, and the organic phase was dried over magnesium sulfate and concentrated. The product with the molecular weight of 501.50 (C22H23F4N3O4S) was obtained in this way; MS (ESI): 502 (M+H+).

المصدر