تفاعل #1563938

معادلة التفاعل

NaNO2

3-(ethoxycarbonyl)-4-fluoropyrazolo[1,5-a]pyridin-5-aminium 2,2,2-trifluoroacetate

HBr

HBr

→

ethyl 5-bromo-4-fluoropyrazolo[1,5-a]pyridine-3-carboxylate

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   أخرىReaction mixture
2. 2
   أخرىwas quenched with ice water
3. 3
   استخلاصextracted into EtOAc
4. 4
   غسيلwashed it with water
5. 5
   تجفيفdried over anhydrous sodium sulphate
6. 6
   تركيزconcentrated under reduced pressure
7. 7
   أخرىto afford crude
8. 8
   أخرىThe crude obtained
9. 9
   أخرىwas purified by column purification (using 60-120 silicagel and 5% EtOAc in Hexane as eluant)

الإجراء التجريبي

NaNO2 (2.26 g, 32.89 mmol) in water (7 mL) was added dropwise at 0° C. to a solution of 3-(ethoxycarbonyl)-4-fluoropyrazolo[1,5-a]pyridin-5-aminium 2,2,2-trifluoroacetate (7 g, 97.5 mmol) in aq.47% HBr (56 mL) and continued stirring at same temperature for 30 min. CuBr (6.29 g, 44 mmol) in aq. 47% HBr (56 mL) was added dropwise to above solution at 0° C. and stirring was continued at 28° C. for 1 hr. Reaction mixture was quenched with ice water, extracted into EtOAc, washed it with water followed by brine, dried over anhydrous sodium sulphate and concentrated under reduced pressure to afford crude. The crude obtained was purified by column purification (using 60-120 silicagel and 5% EtOAc in Hexane as eluant) to afford ethyl 5-bromo-4-fluoropyrazolo[1,5-a]pyridine-3-carboxylate. NMR (300 MHz, DMSO-d6) δ 9.45-9.43 (d, 1H), 8.51 (s, 1H), 8.33-8.30 (d, 1H), 4.35-4.28 (m, 2H), 1.36-1.31 (t, 3H).

المصدر