تفاعل #1563934

معادلة التفاعل

NaBH4

5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole

→

title compound

المردود 79.8%

2-(2,5-difluorophenyl)pyrrolidine

المردود 79.8%

المذيبات

MeOH H2O

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction mixture was quenched with 1N aqueous HCl solution
2. 2
   استخلاصextracted with DCM
3. 3
   تجفيفdried over anhydrous sodium sulphate
4. 4
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

NaBH4 (12 g, 314.9 mmol) was added to a solution of 5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole (28.5 g, 157.4 mmol) in a mixture of MeOH:H2O (4:1, 250 mL) and stirring was continued at 25-35° C. for 2 h. The reaction mixture was quenched with 1N aqueous HCl solution and basified with 2N aqueous NaOH solution, extracted with DCM, dried over anhydrous sodium sulphate and concentrated under reduced pressure to afford 23 g of the title compound.

المصدر