تفاعل #1563890

معادلة التفاعل

Compound 25

2-amino-N-(2-methoxyphenyl)-6-(4-nitrophenylthi-o)benzamide

benzenesulfonyl chloride

→

N-(2-methoxyphenyl)-2-(4-nitrophenylthio)-6-(phenylsulfonamido)benzamide

المردود 67.0%

المذيبات

azabenzene

ظروف التفاعل

المعالجة

1. 1
   تركيزthe reaction mixture was concentrated under reduced pressure
2. 2
   غسيلwashed with water (3×20 mL)
3. 3
   تجفيفdried over anhydrous Na2SO4
4. 4
   ترشيحfiltered
5. 5
   تركيزconcentrated under reduced pressure
6. 6
   أخرىThe residue was purified by silica gel column chromatography (1:4 v/v ethyl acetate/petroleum ether)
7. 7
   أخرىto provide a white solid

الإجراء التجريبي

Compound 25 (1.0 equiv.) was dissolved in azabenzene (40 mL) at room temperature. To this mixture was added benzenesulfonyl chloride (1.2 equiv.). After being stirred for 10 Hours at room temperature, the reaction mixture was concentrated under reduced pressure. The crude residue was diluted ethyl acetate (50 mL), washed with water (3×20 mL), dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (1:4 v/v ethyl acetate/petroleum ether) to provide a white solid. 67% yield;

المصدر