تفاعل #1562969

معادلة التفاعل

2,2-difluoro-7-hydroxy-benzo[1,3]dioxole-5-carboxylic acid methyl ester

1-(bromo-ethyl)-3-methyl-benzene

K2CO3

DMF

→

title compound

المردود 88.4%

2,2-Difluoro-7-(2-m-tolyl-ethoxy)-benzo[1,3]dioxole-5-carboxylic acid methyl ester

المردود 88.4%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto cool to room temperature
2. 2
   استخلاصextracted three times
3. 3
   أخرىThe organic layer was then dried
4. 4
   أخرىevaporated

الإجراء التجريبي

1.8 g of 2,2-difluoro-7-hydroxy-benzo[1,3]dioxole-5-carboxylic acid methyl ester, 4.6 g of 1-(bromo-ethyl)-3-methyl-benzene, and 3.2 g of K2CO3 were added to 70 ml of anhydrous DMF and the reaction mixture stirred at 80° C. for 3 h. The reaction mixture was then allowed to cool to room temperature, 300 ml of water added and extracted three times using 100 ml of EA each. The organic layer was then dried using MgSO4 and evaporated. Chromatography on silica gel using EA/HEP 1:4 yielded 2.4 g of the title compound, colorless oil. Rf (EA/HEP 1:4)=0.32

المصدر