تفاعل #156217

معادلة التفاعل

6-(3-Amino-propoxy)-1-methyl-1H-quinolin-2-one

N-methyl-N-o-tolyl-acrylamide

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title compound

المردود 50.8%

N-Methyl-3-[3-(1-methyl-2-oxo-1,2-dihydro-quinolin-6-yloxy)-propylamino]-N-o-tolyl-propionamide

المردود 50.8%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىcondensed under reduced pressure
2. 2
   أخرىThe residue was purified by silica gel column chromatography (dichloromethane:methanol=20:1→10:1)
3. 3
   أخرىcondensed under reduced pressure

الإجراء التجريبي

6-(3-Amino-propoxy)-1-methyl-1H-quinolin-2-one (194 mg) was added to an ethanol solution (5 ml) of N-methyl-N-o-tolyl-acrylamide (146 mg). The mixture was stirred at room temperature overnight. The reaction mixture was condensed under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane:methanol=20:1→10:1). The purified product was condensed under reduced pressure to give the title compound (172.6 mg) as a colorless oil.

المصدر