تفاعل #155807

معادلة التفاعل

compound 4

Methyl 4-[([(benzyloxy)carbonyl]{4-[(tert-butoxycarbonyl)amino]butyl}amino)methyl]benzoate

sodium hydroxide

→

title compound

4-[([(benzyloxy)carbonyl]{4-[(tert-butoxycarbonyl)amino]butyl}amino)methyl]benzoic acid

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   تركيزThe reaction mixture was concentrated
2. 2
   workup.ADDITIONThe obtained residue was added by 2N hydrochloric acid
3. 3
   استخلاصextracted with ethyl acetate
4. 4
   غسيلThe extract was washed with saturated brine
5. 5
   تجفيفdried over anhydrous sodium sulfate
6. 6
   تركيزconcentrated

الإجراء التجريبي

To a solution of the compound 4 (1.13 g) in methanol (4 mL), an aqueous 2N sodium hydroxide solution (4 mL) was added. The reaction mixture was stirred at room temperature for 3 hours. The reaction mixture was concentrated. The obtained residue was added by 2N hydrochloric acid and then extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous sodium sulfate and then concentrated to obtain the title compound having the following physical properties.

المصدر