تفاعل #155528

معادلة التفاعل

mixture

tert-butyl 3-(3-((4-methoxy-6-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-ylamino)methyl)phenoxy)propylcarbamate

→

title compound

tert-butyl 3-(3-((4-methoxy-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-ylamino)methyl)phenoxy)propylcarbamate

المذيبات

methanol

NaOH

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe mixture was filtered
2. 2
   غسيلthe solid was washed with water
3. 3
   أخرىdried in vacuo

الإجراء التجريبي

A mixture of Example 63B (600 mg, 0.93 mmol) in methanol (12 mL) and NaOH aqueous solution (1M, 4 mL) was stirred at room temperature for 16 hours. The mixture was filtered, and the solid was washed with water and dried in vacuo to give the title compound.

المصدر