تفاعل #155527

معادلة التفاعل

mixture

3-((4-methoxy-6-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-ylamino)methyl)phenol

tert-butyl 3-hydroxypropylcarbamate

triphenylphosphine

diisopropyl azodicarboxylate

→

title compound

tert-butyl 3-(3-((4-methoxy-6-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-ylamino)methyl)phenoxy)propylcarbamate

المذيبات

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   تركيزconcentrated in vacuo
2. 2
   غسيلFlash chromatography isolation (gradient elution, ethyl acetate/hexane 0-50%)

الإجراء التجريبي

To a mixture of Example 63A (0.510 g, 1.05 mmol), tert-butyl 3-hydroxypropylcarbamate (0.275 g, 1.57 mmol) and triphenylphosphine (0.412 g, 1.57 mmol) in tetrahydrofuran (13 ml) was added dropwise diisopropyl azodicarboxylate (DIAD) (0.305 ml, 1.57 mmol). The reaction mixture was stirred at room temperature for 3 hours and then concentrated in vacuo. Flash chromatography isolation (gradient elution, ethyl acetate/hexane 0-50%) gave the title compound.

المصدر