تفاعل #155437

معادلة التفاعل

2-(benzyl(methyl)amino)ethanol

triethylamine

acetic anhydride

CH2Cl2

→

2-(benzyl(methyl)amino)ethyl acetate

المردود 87.5%

المذيبات

MTBE

ظروف التفاعل

المعالجة

1. 1
   أخرىTo a 500 mL dry round bottom flask
2. 2
   غسيلthis mixture was washed
3. 3
   تركيزThe MTBE layer was concentrated
4. 4
   workup.ADDITIONthe residue was poured onto a silica gel pad (200.0 g)
5. 5
   غسيلThe pad was eluted with a co-solvents of ethyl acetate

الإجراء التجريبي

To a 500 mL dry round bottom flask were added 2-(benzyl(methyl)amino)ethanol (46.3 g, 280.2 mmol), triethylamine (150 mL, 1.08 mol), acetic anhydride (31.8 mL, 336.2 mmol), anhydrous CH2Cl2 (100 mL) and a crystal piece of DMAP (4-Dimethylaminopyridine). The mixture was stirred at room temperature for 3 hours. MTBE (700 mL) was added into the reaction mixture, and this mixture was washed, respectively, with cold 2N NaOH (150 mL), water (100 mL), brine (150 mL). The MTBE layer was concentrated, and the residue was poured onto a silica gel pad (200.0 g). The pad was eluted with a co-solvents of ethyl acetate: heptane=3:1 to give 2-(benzyl(methyl)amino)ethyl acetate (50.8 g) as a yellow oil. Yield: 87%. 1H NMR (CDCl3, 300 MHz): δ=7.41-7.25 (m, 5H), 4.29 (t, J=6.3 Hz, 2H), 3.65 (s, 2H), 2.74 (t, J=6.0 Hz, 2H), 2.38 (s, 3H), 2.14 (s, 3H). 13C NMR (CDCl3, 75.5 MHz): δ=170.9, 138.7, 128.9, 128.2, 127.1, 62.5, 62.2, 55.3, 42.6, 21.0.

المصدر