تفاعل #155402

معادلة التفاعل

Boc2O

3-methylene-cyclobutane carboxylic acid

NaN3

→

N-Boc-3-methylene-cyclobutanamine

المردود 34.9%

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated at 45° C. overnight
2. 2
   درجة الحرارةThe reaction was then cooled to 0° C.
3. 3
   أخرىwas quenched with 10% aq. NaNO2 (180 mL)
4. 4
   أخرىThe THF was evaporated
5. 5
   استخلاصthe aqueous layer was extracted with EtOAc (180 mL)
6. 6
   غسيلThe organic layer was washed with 5% aq. NaHCO3 (2×20 mL), brine (30 ml)
7. 7
   تجفيفdried over Na2SO4
8. 8
   ترشيحfiltered
9. 9
   تركيزconcentrated to dryness
10. 10
    أخرىto yield a crude, which
11. 11
    أخرىwas purified by flash chromatography (silica gel/hexanes:ethyl acetate: 0-90%)

الإجراء التجريبي

To a stirring solution of 3-methylene-cyclobutane carboxylic acid (1.0 g, 8.9 mmol) in THF (90 mL) was added NaN3 (2.0 g, 31.1 mmol), followed by tetrabutyl ammonium bromide (0.48 g, 1.5 mmol) and Zn(OTf)2 (0.1 g, 0.3 mmol), and the reaction mixture was heated to 40° C. Boc2O (2.1 g, 9.8 mmol) was then added at once, and the reaction was heated at 45° C. overnight. The reaction was then cooled to 0° C. and was quenched with 10% aq. NaNO2 (180 mL). The THF was evaporated and the aqueous layer was extracted with EtOAc (180 mL). The organic layer was washed with 5% aq. NaHCO3 (2×20 mL), brine (30 ml), dried over Na2SO4, filtered and concentrated to dryness to yield a crude, which was purified by flash chromatography (silica gel/hexanes:ethyl acetate: 0-90%) to yield the desired N-Boc-3-methylene-cyclobutanamine (0.57 g, 3.1 mmol, 34.9% yield): 1H NMR (250 MHz, CDCl3) δ 4.83 (s, 2H), 4.79 (bs, 1H), 4.05-4.23 (m, 1H), 2.92-3.11 (m, 2H), 2.50-2.65 (m, 2H), 1.44 (s, 9H).

المصدر