تفاعل #155397

معادلة التفاعل

HCl

2-chloro-4-(methylsulfonyl)benzoyl chloride

5-amino-1-(2-methoxyethyl)tetrazole

water

→

2-chloro-4-(methylsulfonyl)-N-(1-(2-methoxyethyl)tetrazol-5-yl)-benzamide

المذيبات

EA

pyridine

ظروف التفاعل

المعالجة

1. 1
   أخرىThe organic phase is separated off
2. 2
   غسيلwashed with 2N HCl and brine
3. 3
   تجفيفdried over Na2SO4
4. 4
   تركيزconcentrated
5. 5
   أخرىpurified by RP—HPLC (acetonitrile/water)

الإجراء التجريبي

176 mg (0.75 mmol) of 2-chloro-4-(methylsulfonyl)benzoyl chloride, 145 mg (1.0 mmol) of 5-amino-1-(2-methoxyethyl)tetrazole in 2 ml of pyridine are stirred at 60° C. for 12 h. 0.1 ml of water is then added, the mixture is stirred at 60° C. for 30 min and EA and 2N HCl are added. The organic phase is separated off and washed with 2N HCl and brine, dried over Na2SO4, concentrated and purified by RP—HPLC (acetonitrile/water). Yield 66 mg (23%).

المصدر