تفاعل #155341

معادلة التفاعل

Lithium hydroxide mono-hydrate

water

methyl 3-{2-[5-fluoro-3-(4-methoxyphenyl)-4-oxo-8-propoxy-4H-quinolin-1-yl]ethylsulfanyl}propionate

→

3-{2-[5-fluoro-3-(4-methoxyphenyl)-4-oxo-8-propoxy-4H-quinolin-1-yl]ethylsulfanyl}propionic acid

المردود 82.3%

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   غسيلThe reaction mixture was washed with ethyl acetate
2. 2
   workup.ADDITION2N hydrochloric acid was added to the water layer
3. 3
   أخرىThe generated insoluble matter was separated
4. 4
   غسيلwashed with water
5. 5
   أخرىdried

الإجراء التجريبي

Lithium hydroxide mono-hydrate (31 mg, 0.74 mmol) and water (5 ml) were added to an acetonitrile solution (10 ml) of methyl 3-{2-[5-fluoro-3-(4-methoxyphenyl)-4-oxo-8-propoxy-4H-quinolin-1-yl]ethylsulfanyl}propionate (175 mg, 0.37 mmol), and the mixture was stirred at room temperature for 2 hours. The reaction mixture was washed with ethyl acetate, and then 2N hydrochloric acid was added to the water layer to make the mixture acidic. The generated insoluble matter was separated, washed with water and then dried, giving a white powder of 3-{2-[5-fluoro-3-(4-methoxyphenyl)-4-oxo-8-propoxy-4H-quinolin-1-yl]ethylsulfanyl}propionic acid (140 mg, yield: 82%).

المصدر