تفاعل #1553217

معادلة التفاعل

water

1-(Methoxymethylene)indane-5-carbonitrile

BBr3

→

1-Formylindane-5-carbonitrile

المذيبات

DCM

ظروف التفاعل

المعالجة

1. 1
   استخلاصThe mixture was extracted with DCM
2. 2
   غسيلThe combined organic layer was washed with brine
3. 3
   تجفيفdried over anhydrous Na2SO4
4. 4
   تركيزconcentrated

الإجراء التجريبي

To a solution of 1-(Methoxymethylene)indane-5-carbonitrile (1.5 g, 8.1 mmol) in DCM (40 mL) was added BBr3 (6 g, 24 mmol) at −78° C. The mixture was stirred for 3 hours at −78° C. Then water was added. The mixture was extracted with DCM. The combined organic layer was washed with brine, dried over anhydrous Na2SO4 and concentrated to give the crude 1-Formylindane-5-carbonitrile, which was used for next step without further purification. MS m/z: 172 [M+1]+.

المصدر